From small molecules to complex organelles

Latest News

  • April 20, 2020 Ubiqutin & Friends Symposium 2020, 14-15 May Due to the COVID-19 pandemic, this year’s Ubiquitin & Friends Symposium will take place virtually via Zoom on 14th and 15th of May 2020, with an exciting program and a stellar line-up of invited speakers. Registration is open until 5 May 2020. Read more →
  • December 5, 2019 Funding for a Special Research Program in Targeted Protein Degradation The Austrian Science Fund has awarded one of the prestigious Special Research Program (SFB) grants to a consortium of scientists in Vienna and Mainz to unravel mechanisms of targeted protein degradation. Read more →

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About the Programme

Targeted Protein Degradation: From small molecules to complex organelles

Our Special Research Program is a collaborative research platform to unravel how proteins are targeted for degradation. We focus on the two major cellular proteolytic pathways, the ubiquitin-proteasome system (UPS) and autophagy, and the crosstalk between them in the cytoplasm and in the nucleus. Furthermore, we investigate how small molecules can be used to chemically reprogram the degradation systems, enabling the targeted proteolysis of selected proteins in a spatially and temporally controlled manner …

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Selected Publications

  • 2020 A PI3K-WIPI2 positive feedback loop allosterically activates LC3 lipidation in autophagy Journal of Cell Biology (in press) Fracchiolla D, Chang C, Hurley JH, Martens S Go to publication →
  • 2019 A repetitive acidic region contributes to the extremely rapid degradation of the cell-context essential protein TRIM52 Sci. Rep. Hacker K, Benke S, Agerer B, Scinicariello S, Budroni V, Versteeg GA Go to publication →
  • 2016 Arginine phosphorylation marks proteins for degradation by a Clp protease Nature Trentini DB, Suskiewicz MJ, Heuck A, Kurzbauer R, Deszcz L, Mechtler K, Clausen T Go to publication →